Molly Mae uses PDRN. So… should you?👀
If you’ve been anywhere near Beauty TikTok lately, you’ll probably have seen PDRN everywhere.And when Molly-Mae recently referenced the Medicube PDRN Pink Peptide Serum, we had to find out what all the fuss was about. Because suddenly, PDRN seemed to be the ingredient everyone was talking about.
So, what actually is PDRN — and is it worth the hype?
PDRN stands for polynucleotide, and it refers to purified DNA fragments traditionally sourced from salmon or trout. It has become a major ingredient in Korean skincare, particularly in products designed around skin repair, hydration and overall skin health. The appeal? PDRN is associated with supporting the skin’s natural renewal processes, while helping create a smoother, more hydrated and plumper-looking complexion.
It’s also worth noting that PDRN isn’t exactly a new discovery. It has been used in professional and medical settings for years, but its popularity in skincare has exploded more recently, thanks in no small part to K-beauty and social media.
Now, you’ll find everything from PDRN serums and ampoules to toners and moisturisers - check out our guide below!
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Medicube PDRN Pink Peptide Serum -The viral one
MEDICUBE PDRN Pink Peptide Serum
The viral pink bottle that seems to be everywhere right now. Medicube’s PDRN Pink Peptide Serum combines PDRN with peptides to target hydration, plumpness and smoother-looking skin. It’s become one of the most recognisable products in the PDRN skincare boom, and the one that has arguably put the ingredient on everyone’s radar.
Best for: Anyone wanting to try the viral PDRN trend for the first time, particularly if you’re looking for hydrated, plumper-looking skin.
ANUA PDRN Hyaluronic Acid 100 Moisturizing Cream - The hydrating one
ANUA PDRN Hyaluronic Acid 100 Moisturizing Cream
ANUA takes the PDRN trend in a more hydration-focused direction. The moisturiser combines PDRN with hyaluronic acid, making it a particularly interesting option if your main skincare priority is keeping your complexion hydrated, soft and plump-looking.
Best for: Dry or dehydrated skin, or anyone who wants to incorporate PDRN into their routine through a moisturiser rather than another serum.
REJURAN Healer Turnover Ampoule - The premium one
REJURAN Healer Turnover Ampoule
REJURAN is one of the names most closely associated with the PDRN and polynucleotide space. Its Healer Turnover Ampoule is a more premium take on the trend, formulated around skin regeneration, hydration and overall skin health. It does come with a considerably higher price tag, though, so this is one for the serious PDRN enthusiasts.
Best for: Anyone looking to invest in a more premium PDRN product and make skin health and regeneration the focus of their routine.
Numbuzin No.9 NAD+ PDRN Glow Boosting Toner - The toning one
NUMBUZIN No.9 NAD+ PDRN Glow Boosting Toner
PDRN has officially moved beyond the serum step, and into toner territory. Numbuzin’s No.9 combines PDRN with NAD+ in a glow-focused formula designed to hydrate and leave skin looking smoother, fresher and more radiant.
Best for: Anyone who already has their serum routine sorted and wants to add PDRN through a hydrating, glow-boosting toner.
Revolution Pro Miracle PDRN & Pink Peptide Serum - The budget-friendly one
REVOLUTION PRO Miracle PDRN & Pink Peptide Serum
f the price tags attached to some of the more premium PDRN products are putting you off, Revolution Pro offers a much more accessible way into the trend. Its Miracle PDRN & Pink Peptide Serum combines PDRN and pink peptides to target hydration, plumpness and smoother-looking skin without the premium price tag.
Best for: PDRN beginners who want to experiment with the trend without spending too much.
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